A 3-D Admittance-Level Computational Model of a Rat Hippocampus for Improving Prosthetic Design
Gilbert, Andrew ; Loizos, Kyle ; RamRakhyani, Anil ; Hendrickson, Phillip ; Lazzi, Gianluca ; Berger, Theodore
Multiscale modeling
,
Medical device modeling
Hippocampal prosthetic devices have been developed to bridge the gap between functioning portions of the hippocampus, in order to restore…
A Million-Plus Neuron Model of the Hippocampal Dentate Gyrus: Dependency of Spatio-Temporal Network Dynamics on Topography
Hendrickson, Phillip ; Yu, Gene ; Song, Dong ; Berger, Theodore
Brain physiology and modeling – Neuron modeling and simulation
This paper describes a million-plus granule cell compartmental model of the rat hippocampal dentate gyrus, including excitatory, perforant path…
Design of a Flexible Parylene-Based Multi-Electrode Array for Multi-Region Recording from the Rat Hippocampus
Xu, Huijing ; Hsiao, Min-Chi ; Meng, Ellis ; Berger, Theodore ; Song, Dong
Neural interfaces – Microelectrode technology
,
Neural interfaces – Implantable systems
,
Brain physiology and modeling – Cognition, memory, perception
The hippocampus is a critical deep brain structure in several aspects. It is directly related to the formation of new long-term declarative…
Estimation of a Large-Scale Generalized Volterra Model for Neural Ensembles with Group Lasso and Local Coordinate Descent
Robinson, Brian ; Song, Dong ; Berger, Theodore
Brain physiology and modeling – Neural dynamics and computation
,
Neural signals – Nonlinear analysis
,
Brain physiology and modeling – Neuron modeling and simulation
Estimation of neural models based on observed spike timing faces challenges as the amount of recorded units increases, especially when…
Sparse Generalized Volterra Model of Human Hippocampal Spike Train Transformation for Memory Prostheses
Song, Dong ; Robinson, Brian ; Hampson, Robert ; Marmarelis, Vasilis ; Deadwyler, Sam ; Berger, Theodore
Brain physiology and modeling – Neural dynamics and computation
,
Brain physiology and modeling – Cognition, memory, perception
,
Neural signals – Nonlinear analysis
In order to build hippocampal prostheses for restoring memory functions, we build multi-input, multi-output (MIMO) nonlinear dynamical models of…
The Volterra Functional Series is a Viable Alternative to Kinetic Models for Synaptic Modeling – Calibration and Benchmarking
Hu, Eric ; Bouteiller, Jean-Marie Charles ; Song, Dong ; Berger, Theodore
Multiscale modeling
,
Modeling of biomolecular system dynamics
,
Algorithms and techniques for systems modeling
Synaptic transmission is governed by a series of complex and highly nonlinear mechanisms and pathways in whichthe dynamics have a profound…
Topography-Dependent Spatio-Temporal Correlations in the Entorhinal-Dentate-CA3 Circuit in a Large-Scale Computational Model of the Rat Hippocampus
Yu, Gene ; Hendrickson, Phillip ; Song, Dong ; Berger, Theodore
Brain physiology and modeling – Neuron modeling and simulation
The correlation due to different topographies was characterized in a large-scale, biologically-realistic, computational model of the rat…
